ESAT-6-gpi DNA Vaccine Augmented the Specific Antitumour Efficacy Induced by the Tumour Vaccine B16F10-ESAT-6-gpi/IL-21 in a Mouse Model
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منابع مشابه
Esat-6 as an Effective Mycobacterium Tuberculosis Subunit Vaccine
Tuberculosis is still one of the important infectious diseases and a major cause for public health problems, particularly in lowand middle-income countries. Prevention of this disease is a priority of WHO. Many antigens have been candidate for vaccination. Evaluating the safety and efficacy of these antigens is the concern of many researchers. This review is about ESAT-6 as an effective Mycobac...
متن کاملAg85A/ESAT-6 chimeric DNA vaccine induces an adverse response in tuberculosis-infected mice
The Mycobacterium tuberculosis (M. tb) antigens encoded by the 6 kDa early secretory antigenic target (esat-6) and antigen 85A (ag85a) genes are known to exert protective effects against tuberculosis in animal models. In addition, these antigens represent vaccine components that were tested in early human clinical trials. In the present study, a chimeric DNA vaccine was constructed that contain...
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There is a need for an improved vaccine for tuberculosis. ESAT-6 is a cardinal vaccine antigen with unique properties and is included in several vaccine candidates in development. ESAT-6 is also the core antigen in the IFN-γ release assays (IGRA) used to diagnose latent infection, rendering IGRA tests unspecific after vaccination. This challenge has prompted the development of a companion diagn...
متن کاملPolyethylenimine modified nanoparticle adjuvant increases therapeutic efficacy of DNA vaccine Ag85A-ESAT-6-IL-21 in mice infected with Mycobacterium tuberculosis
Despite considerable research efforts, the treatment of tuberculosis (TB) remains to be a great challenge in the requirement of prolonged therapy with multiple high-dose drugs and associated side effects. As such, the development of an effective vaccine to treat TB may be feasible strategy. The aim of this study was to investigate the possibility of polyethylenimine (PEI) modified nanoparticle ...
متن کاملA novel recombinant DNA vaccine encoding Mycobacterium tuberculosis ESAT-6 and FL protects against Mycobacterium tuberculosis challenge in mice
Mycobacterium tuberculosis 6-kDa early secretory antigenic target (ESAT-6) is a dominant target antigen for cell-mediated immunity in the early phase of tuberculosis. The fms-like tyrosine kinase 3 ligand (FL) that induces potent immune response has been used as an adjuvant in vaccine development. In this study, a new recombinant plasmid (pIRES-epitope-peptides-FL) encoding three T cell epitope...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2013
ISSN: 0300-9475
DOI: 10.1111/sji.12074